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RG 13022

CAS No. 136831-48-6

RG 13022 ( RG 13022 | RG-13022.Tyrphostin RG 13022 )

产品货号. M17260 CAS No. 136831-48-6

RG13022 是一种酪氨酸激酶抑制剂;抑制 EGF 受体的自磷酸化反应(IC50:4 μM)。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥316 有现货
5MG ¥446 有现货
10MG ¥648 有现货
25MG ¥1531 有现货
50MG ¥2592 有现货
100MG ¥4099 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    RG 13022
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    RG13022 是一种酪氨酸激酶抑制剂;抑制 EGF 受体的自磷酸化反应(IC50:4 μM)。
  • 产品描述
    RG-13022 is an inhibitor of epidermal growth factor (EGF) receptor kinase with an IC50 value of 1 μM in HT-22 cells. Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs.
  • 体外实验
    RG13022 suppresses EGF-stimulated cancer cell proliferation. In a cell-free reaction RG13022 inhibits the autophosphorylation reaction of the EGF receptor in immunoprecipitates with an IC50 of 4 μM. RG13022 inhibits colony formation and DNA synthesis by HER 14 cells, which were stimulated by 50 ng/mL EGF, in a dose-dependent manner. The IC50s are 1 and 3 μM for HER 14 colony formation and DNA synthesis, respectively. RG-13022 inhibits not only EGF-induced growth but also growth stimulated by insulin, insulin-like growth factor I, insulin-like growth factor II, or transforming growth factor alpha. RG-13022 also totally blocks estrogen-stimulated phosphorylation of the EGF receptor, as well as estrogen-induced cell proliferation, suggesting that functioning TK pathways are required for estrogen action.
  • 体内实验
    RG13022 suppresses tumor growth in nude mice. RG13022 also increases the life span of these tumor-bearing nude mice.
  • 同义词
    RG 13022 | RG-13022.Tyrphostin RG 13022
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    EGFR
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    136831-48-6
  • 分子量
    266.29
  • 分子式
    C16H14N2O2
  • 纯度
    >98% (HPLC)
  • 溶解度
    In Vitro:?DMSO : 100 mg/mL (375.53 mM)
  • SMILES
    COc1c(cc(cc1)/C=C(\C#N)/c1cnccc1)OC
  • 化学全称
    3-Pyridineacetonitrile, alpha-((3,4-dimethoxyphenyl)methylene)-

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Yoneda T,et al. The antiproliferative effects of tyrosine kinase inhibitors tyrphostins on a human squamous cell carcinoma in vitro and in nude mice. Cancer Res. 1991 Aug 15;51(16):4430-5.
产品手册
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