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RG 13022
CAS No. 136831-48-6
RG 13022 ( RG 13022 | RG-13022.Tyrphostin RG 13022 )
产品货号. M17260 CAS No. 136831-48-6
RG13022 是一种酪氨酸激酶抑制剂;抑制 EGF 受体的自磷酸化反应(IC50:4 μM)。
纯度: >98% (HPLC)
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规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥316 | 有现货 |
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5MG | ¥446 | 有现货 |
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10MG | ¥648 | 有现货 |
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25MG | ¥1531 | 有现货 |
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50MG | ¥2592 | 有现货 |
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100MG | ¥4099 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称RG 13022
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述RG13022 是一种酪氨酸激酶抑制剂;抑制 EGF 受体的自磷酸化反应(IC50:4 μM)。
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产品描述RG-13022 is an inhibitor of epidermal growth factor (EGF) receptor kinase with an IC50 value of 1 μM in HT-22 cells. Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs.
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体外实验RG13022 suppresses EGF-stimulated cancer cell proliferation. In a cell-free reaction RG13022 inhibits the autophosphorylation reaction of the EGF receptor in immunoprecipitates with an IC50 of 4 μM. RG13022 inhibits colony formation and DNA synthesis by HER 14 cells, which were stimulated by 50 ng/mL EGF, in a dose-dependent manner. The IC50s are 1 and 3 μM for HER 14 colony formation and DNA synthesis, respectively. RG-13022 inhibits not only EGF-induced growth but also growth stimulated by insulin, insulin-like growth factor I, insulin-like growth factor II, or transforming growth factor alpha. RG-13022 also totally blocks estrogen-stimulated phosphorylation of the EGF receptor, as well as estrogen-induced cell proliferation, suggesting that functioning TK pathways are required for estrogen action.
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体内实验RG13022 suppresses tumor growth in nude mice. RG13022 also increases the life span of these tumor-bearing nude mice.
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同义词RG 13022 | RG-13022.Tyrphostin RG 13022
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通路Others
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靶点Other Targets
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受体EGFR
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研究领域——
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适应症——
化学信息
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CAS Number136831-48-6
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分子量266.29
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分子式C16H14N2O2
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 100 mg/mL (375.53 mM)
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SMILESCOc1c(cc(cc1)/C=C(\C#N)/c1cnccc1)OC
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化学全称3-Pyridineacetonitrile, alpha-((3,4-dimethoxyphenyl)methylene)-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Yoneda T,et al. The antiproliferative effects of tyrosine kinase inhibitors tyrphostins on a human squamous cell carcinoma in vitro and in nude mice. Cancer Res. 1991 Aug 15;51(16):4430-5.
产品手册
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